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Cosmetic ingredient HyWhite (whitening sodium hyaluronate derivative)

Hyaluronic Acid Na for Whitening that Maximizes the Function of Alpha-Linolenic Acid

HyWhite is a sodium hyaluronate with whitening (brightening) properties manufactured by Contipro in the Czech Republic. HyWhite is a product that has high whitening (brightening) effects, made by partially replacing low molecular weight sodium hyaluronate with alpha-linolenic acid, which has high permeability to the skin. Alpha-linolenic acid is widely known for its strong melanin production suppression effects, and in in-vitro results, it has been confirmed to have a higher suppression effect than kojic acid. On the other hand, it is also known as a component that is difficult to formulate due to its low skin permeability and instability. This product promotes the absorption of alpha-linolenic acid, which has been a problem in the past, by replacing part of the low molecular weight hyaluronate with alpha-linolenic acid, thereby improving stability and maximizing the effects of alpha-linolenic acid. *In addition to HyWhite, Contipro also manufactures sodium hyaluronate, hydrolyzed sodium hyaluronate, and other hyaluronate derivatives.

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Hair care ingredients: scalp microbiome, anti-hair loss, hair lirin.

Scalp microbiome regulation, slowing hair loss, improving hair health and hair density, promoting Wnt/β-catenin signaling.

Alopecia is a common disorder caused by the miniaturization of hair follicles, leading to the softening of hair. The most common type of hair loss is androgenetic alopecia, which accounts for 90% of cases, with 28% of men aged 18-29 and 53% of men over 40 being affected by this condition. From a pathophysiological perspective, the causes of alopecia are multifactorial, including stress, nutrition, exposome, genetic predisposition, and hormonal sensitivity. The scalp microbiome has a significant relationship with hair growth disorders. Finding the optimal balance of both bacterial and fungal communities in hair is a step towards maintaining healthy hair. GREENTECH has developed anti-hair loss ingredients aimed at normalizing the scalp microbiome and regenerating follicular cells, focusing on the Wnt pathway, which plays a key role in the hair follicle and hair growth cycle. In Vitro 1) Inhibition of key signaling pathways for hair growth: - DDK-1 inhibition: 89% - TGFβ1 inhibition: 55% - sFRP-1 inhibition: 21% - Endothelin-1 inhibition: 21% 2) Increased proliferation of dermal papilla cells: 41% increase (better than minoxidil) 3) Adjustment of the microbiome In Vivo Hair density: 28.5% improvement

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Cosmetic ingredients Skin microbiome improvement ingredient Biotilis

Skin microbiome, promotion of antimicrobial peptide production, anti-inflammatory effects, barrier function recovery effects, enhancement of tight junction barrier function.

BIOTILYS enhances the expression of antimicrobial peptides, improving antibacterial activity, anti-inflammatory effects, barrier function recovery, and the diversity of the skin microbiome. <Effects of Antimicrobial Peptides> - Antimicrobial peptides have a broad range of antibacterial activity and have been reported to exhibit antibacterial activity against Gram-positive Staphylococcus aureus, Gram-negative Pseudomonas aeruginosa, and even drug-resistant bacteria. - They have also been confirmed to improve tight junction barrier function and have anti-inflammatory effects on the skin, showing promise for the treatment of atopic dermatitis and psoriasis. <Stimuli for Antimicrobial Peptide Expression> - β-defensin 2 (hBD2): +229% - β-defensin 3 (hBD3): +19% - S100A7 (soriacin): +237% <Anti-inflammatory> - Toll-like receptor 2 (TLR2): -57% - IL-8: -58% <In Vivo: Barrier Function Recovery Effects> - Water vapor loss: -31% (after 6 hours) - Moisturizing function: +27% (after 3 hours) - Improvement in the diversity of the skin microbiome

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Cosmetic Ingredients Comprehensive Catalog of Skin and Scalp Microbiome Products

Microbiome, antimicrobial peptides, anti-dandruff, scalp care, hair growth, hair regrowth, barrier function recovery, sensitive skin relief, moisturizing, redness suppression, skin-friendly bacteria.

Human skin is a complex and diverse ecosystem. It is home to not only human skin cells but also bacteria, fungi, viruses, and mites, making it one of the very complex ecosystems that are still not well understood. When the balance of the skin microbiome is disrupted, it can affect skin health. Changes in resident skin bacteria have been confirmed to be related to skin concerns (such as acne, dryness, redness, hair loss, and dandruff) that are focused on in skincare and haircare. Green Tech Company believes that cosmetics targeting the microbiome could become one of the effects that consumers will prioritize in the future, and they are developing various products. <Product Information> - EXPOZEN: Reduces the stinging sensation and redness of sensitive skin, anti-wrinkle effect - BIOTILYS: Promotes the production of antimicrobial peptides, suppresses harmful bacteria, enhances the diversity of symbiotic bacteria, restores barrier function - ACNILYS: Suppresses acne-causing bacteria IA1 (maintains the balance of symbiotic bacteria), improves acne, reduces sebum, inhibits 5-alpha reductase - DANDRILYS: Improves dandruff, alleviates itching, reduces sebum, suppresses bacteria related to sebum secretion, improves the balance of resident bacteria - HAIRILINE: Suppresses bacteria related to hair loss, restores bacterial balance, promotes hair growth

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Cosmetic ingredients for sensitive skin, microbiome-regulating anti-exposome.

Skin microbiome adjustment for sensitive skin, pain suppression, TRPV-1 inhibition, suppression of bacteria causing redness, erythema suppression, anti-wrinkle, anti-exposome.

Today, it is said that 50% of women in Europe, America, and Japan have sensitive skin. Regardless of the presence of erythema, sensitive skin experiences excessive reactions to environmental factors, accompanied by sensations such as stinging and itching. These factors can be external (such as UV rays and chemicals) or internal (such as stress and hormones), and in most cases, they cause discomfort to the skin and visible symptoms. Additionally, it is believed that skin microbiota are involved in the symptoms of sensitive skin. In response to this significant challenge, GREENTECH has developed a functional product, ExpoZen, to protect the skin from harmful exposomes. In Vitro: Effects on inflammation and neurogenic inflammation suppression: - TRPV-1: -67% - TNF-α: -21% - NK1-R: -43% - VEGF: -16% Effects on barrier function improvement: - Increased epidermal thickness: +12% In Vivo: Microbiome regulation: - Suppression of bacteria associated with inflammation and redness (C. Kroppenstedtii) - Increase of beneficial bacteria (S. epidermis) Improvement of sensitive skin symptoms: - Skin irritation: -34% - Pain: -33% - Tingling: -40% - Erythema: -24%

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Body care ingredients: Thymilin, a cellulite removal ingredient that acts on fat cells.

Inhibition of mature adipocytes, cellulite removal, slimming, collagen production, activation of lipase, inhibition of adipocyte hypertrophy, inhibition of lipid integrity, inhibition of fat accumulation.

Timiline is a polyglucuronic acid obtained by purifying bacterial fermentation products and chemically modifying them. Greentech developed Timiline as a cellulite removal ingredient based on transcriptome analysis using DNA chips, screening 44,000 human genes and finding that Timiline promotes the expression of the FIAF adipokine gene. <Mechanism of Action> TIMILINE targets four factors to remove cellulite: - It inhibits LPL to reduce lipid biosynthesis and fat accumulation. - It stimulates ATGL to break down accumulated fat and release it extracellularly. - It promotes the transport of fatty acids from subcutaneous tissue to peripheral tissue. - It suppresses the differentiation of preadipocytes into mature adipocytes. <Efficacy> In Vitro - Suppression of intracellular lipids: -26% - Inhibition of differentiation of preadipocytes into mature adipocytes - Promotion of production: collagen +30%, integrin +17%, glycosaminoglycan +17% - Promotion of integrin production: In Vivo - Cellulite removal: improvement in 64% of subjects - Thigh circumference: approximately 67% reduction - Improvement in elasticity: 67% reported feeling it - Improvement in dimpling: 53% reported feeling it

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Hair care ingredients: 9 plant extracts that promote healthy hair, Phyteren 232.

Nourishes hair, hair care, contains 9 plant extracts, scalp sebum control, keeps the scalp clean, activates the scalp, complex product.

Fiteren Hair Care EGX232 is a complex product that combines extracts from nine effective hair care ingredients. This product contains extracts with effects such as hair growth stimulation, anti-inflammatory properties, antibacterial effects, improved blood circulation, and nutritional components for hair, helping to keep hair and scalp healthy and beautiful. <Roles of Plant Extracts> - It is expected to improve blood flow to the microcirculation and increase blood flow to the hair roots, enhancing the supply of nutrients and oxygen to the hair roots. Extracts from Arnica flowers and Garlic roots: Blood pressure-lowering effects Extract from Lamium album flowers: Blood circulation-promoting effects - It is expected to protect a clean scalp environment. Extracts from Arnica flowers, Burdock roots, Garlic roots, Chamomile flowers, European Pine cones, and Rosemary leaves: Anti-dandruff effects through the antibacterial action against bacteria and fungi related to seborrhea, as well as anti-inflammatory effects. - It is expected to promote hair growth and regulate sebum secretion. Extracts from Arnica flowers, Burdock roots, Garlic roots, Chamomile flowers, and Watercress: Rich in components necessary for hair growth and regulation of sebum secretion. - It is expected to activate the scalp. Extract from English Ivy: Contains saponins and has the function of removing excess sebum.

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Hair Care Ingredient Conditioning Seaweed Extract Complex 771

Seaweed extract, complex, hair care, conditioning, active oxygen protection, scalp moisturizing, scalp circulation promotion, cuticle improvement.

The Fiteren Hair Conditioning EGX771 is a complex product that promotes overall hair health. Green Tech has carefully selected and combined marine plants that have synergistic and supplementary effectiveness for hair health, developing a complex product that promotes scalp circulation, moisturizes, supports hair growth, and improves cuticles. <Ingredients> Uronic polysaccharides, sulfated polysaccharides, polyphenols, vitamin B group, amino acids, proteins, minerals, salts, etc. - Nutrients for hair follicles Peptides and vitamin B group are expected to have hair growth effects. - Scalp circulation promotion Polysaccharides, fucoidan, fucan, laminarin: blood pressure-lowering effects Polyphenols: improve the mechanical strength of hair. - Hair growth effects Dulse: rich in vitamin B group, which is excellent for hair growth effects. - Hair treatment, cuticle improvement effects, scalp moisturizing effects Sulfated polysaccharides: interact with amino acids in the stratum corneum and hair keratin, protecting while moisturizing the scalp and hair. - Antioxidant and anti-pollution effects Polyphenols derived from Ascophyllum and Sakhalin kelp, and vitamin C derived from wakame and dulse: neutralize reactive oxygen species. Polysaccharides: form a water-soluble film and exhibit barrier functions.

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Cosmetic ingredient: Moisturizing component from Provence-grown mask melon, HYDRALYS.

Upcycled materials, Provence-grown, mask melon fruit, NMF, natural moisturizing factors, free sugars.

This product is an upcycled fruit extract made from non-standard mask melons. It is rich in free sugars, a natural moisturizing factor, which hydrates the skin and keeps it supple and healthy. In Vivo: - Skin moisture level After 1 hour: +54% After 6 hours: +36%

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Cosmetic ingredient Carboxymethylglucan (natural polysaccharide)

Immune modulation, antioxidant effect, promotion of superoxide dismutase (reactive oxygen species decomposition enzyme) production, anti-aging (elasticity, wrinkles, smoothness)

Carboxymethyl glucan (CMG) is a derivative of β-glucan isolated from yeast cell walls and is a natural yeast polysaccharide. While β-glucan is insoluble, this product has been made water-soluble while maintaining its biological activity through carboxymethylation. CMG significantly increases superoxide dismutase (SOD) activity, which shows important immune-regulating and antioxidant effects. These mechanisms help protect the skin from UV stress. = In Vitro = - Maintenance of glutathione pool (UV) - Promotion of SOD (reactive oxygen species-decomposing enzyme) production (UV): 40% increase - Inhibition of cellular phospholipid oxidation (UV): 80% inhibition - Inhibition of cellular protein oxidation (UV, vs TiO2): 22% inhibition - Inhibition of inflammatory cytokine (IL-6) (UV): 20% inhibition - Inhibition of inflammatory cytokine (IL-1beta) (UV): 40% inhibition - Promotion of anti-inflammatory cytokine (IL-10) production (UV): 60% increase = In Vivo = - Increase in collagen fibers and dermal papilla cells - Improvement in skin smoothness - Reduction in pore size - Improvement in skin elasticity - Improvement in crow's feet wrinkles

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Body care ingredient, odor-eliminating component that regulates the bacterial flora, lactoferrin.

Deodorizing ingredients, body care, antibacterial effect, selective disinfection, staphylococcus, corynebacterium, staphylococcus, antibacterial deodorization, armpit odor suppression, body odor suppression.

The skin is a barrier between the internal body and the external environment. The epidermis, which is exposed to the external environment, is home to a diverse microbiome. This microbiome includes bacteria that metabolize components secreted in sweat and sebum, converting them into volatile substances. These volatile substances are the cause of body odor. The repeated use of deodorant products with antibacterial effects indiscriminately kills skin resident bacteria, posing a risk of damaging the skin's natural microbiome. Therefore, GREENTECH has focused on the antibacterial properties of the lactic acid bacterium Lactococcus lactis and developed LACTOPHYT, a component that selectively kills odor-causing bacteria. =Effects= Suppresses odor-causing bacteria Maintains beneficial bacteria Reduces axillary odor =In Vitro= <Commensal Bacteria> Staphylococcus epidermidis: 24h–72h: + <Odor-Causing Bacteria> S. HOMINIS: 24h–48h: - C. XEROSIS: 24h–72h: - C. TUBERCULOSTEARICUM: 24h–72h: - *S.: Staphylococcus, C.: Corynebacterium =In Vivo= Body odor intensity: -30% (Day 1), -35% (Day 3)

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Cosmetic ingredient turnover-promoting enzyme protease (subtilisin)

Keratin care, turnover promotion, exfoliation promotion, smoothing the skin, wrinkle improvement, nutrient permeability promotion, anti-aging, skin regeneration, AHA alternative, powder.

This product is an enzyme refined from Bacillus subtilis using cutting-edge technology. Mechanism of Action: Skin aging leads to dysfunction between the exfoliation and adhesion mechanisms, resulting in thickening of the stratum corneum and abnormal retention of keratinocytes. The skin becomes saggy and wrinkled. By using PROTEASE (an extracellular enzyme found in the stratum corneum), peptide bonds are cleaved, inducing the dissolution of desmosomes. The processes of desquamation and cell regeneration are enhanced, slowing down skin aging. The skin's contours become smoother, and nutrient penetration is improved. Efficacy: - Improves the radiance of the complexion by stimulating the desquamation and cell turnover processes. - Smooths the skin's contours, reducing wrinkles and improving blemishes. - Promotes the penetration of nutrients. In Vitro: Approach to the stratum corneum - Adhesion improvement: +49% - Exfoliation promotion effect: +66%

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Hair care ingredients: Anti-hair loss complex with four extracts.

Extracts from Kigelia fruit, Ginkgo leaves, Clary sage, and cinnamon bark are expected to have anti-hair loss effects.

This product (Capillary Complex) is an anti-hair loss product made from extracts of four plants. <Active ingredients and effectiveness of each plant> - Clary Sage: Flavonoids, Terpenes, Rosmarinic Acid / Antioxidant function, Anti-inflammatory action - Cinnamon: Tannins / Relaxation effect, Activation effect, Microcirculation promotion effect - Ginkgo: Flavonoids, Diterpenes / Anti-inflammatory action, Vasodilatory effect - Kigelia: Flavonoids, Saponins / Vasodilatory effect, 5α-reductase inhibitory effect In Vivo: - Microcirculation promotion effect: +18% (60 minutes after application) - Sebum secretion suppression effect: -32% (after 60 days of application) - Hair loss suppression effect: -30% (after 60 days of application)

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